The Examination of Remodeling Processes of Hard Periodontal Tissues in Rats with Disorders of Pancreatic Incretory Function

Topicality. Pancreatic hormones play an important role in the process of remodeling hard periodontal tissues. Violations carbohydrate metabolism that occur under conditions isolated insulin resistance (IR) and combination with iodine deficiency (ID) can be cause dysmetabolic disorders mineralization/demineralization physiological system tooth-maxillary complex.
 The aim. To study changes processes tissues rats IR impaired glucose tolerance against background ID.
 Materials methods. examination was carried on 90 male rats, which were divided into three groups: control (intact animals), group adequate supply, ID. studied by level blood serum, glycosylated hemoglobin (HbA1c) following calculation HOMA-IR index. detected content calcium, magnesium, zinc, manganese, copper cementum tooth root alveolar process, activity acid alkaline phosphatases serum.
 Results. Keeping animals a high-fructose diet led to development (increase HbA1c levels, serum insulin, index) (decrease magnesium manganese increase zinc root; decrease macroelements process; activation phosphatase inhibition activity). combined endocrinopathy accompanied more pronounced parameters.
 Conclusions. violation ID slows down mineralization mainly due intensification osteoresorptive processes.
 Keywords: phosphatases; calcium homeostasis; bioelement panel system; resistance; deficiency.